Bioinformatician/sr. Bioinformatician, Functional

APPLICATION CLOSING DATE: 15th September 2023

Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers: Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

The Functional Genomics Computation Scientific Service Unit is looking for a Bioinformatician in the R esearch Centre for Genomics - F unctional Genomics Programme.

We are looking for a Bioinformatician in the Functional Genomics Computation Unit , a new state-of-the-art unit for the analysis of functional genomics data deriving from a variety of technologies and approaches. This unit is strongly integrated within the research groups in the Research Centre for Genomics, supporting the data analyses efforts of the groups at all steps of scientific projects, from data generation to publication. The Unit benefits from a large High-Performance Computing and Data Storage infrastructure, and from close interaction with an expert community of computational biologists within the Research Centre for Genomics, other Research Centres, and core facilities at HT.

Key tasks and responsibilities :

• Setting up and operating bioinformatics analysis pipelines/libraries to process transcriptomics and functional genomics data, using short
• and long-read technologies, including but not limited to genomics analysis from bulk, single cell genomics and multiomics datasets.
• Design, set up and maintain data analysis pipelines and software for genomics analysis downstream of the pipelines (eg. identification and functional annotation of regulatory elements, transcripts, etc.; statistical analyses of experimental results; integration of genomic, epigenomic and other datasets).
• Setting up processing and analyses approaches for novel experimental assays.
• Manage import, storage and use of external datasets (eg: ENCODE, Human Cell Atlas, FANTOM), including control of appropriate access rights and data annotation.
• Manage storage and maintenance of genetic and genomic datasets produced by the research groups, curation of data for depositions in public repositories. Data harmonization of genomic resources; curation of metadata of experiments.
• Provide support, training and supervision to members of the department (students and staff) on scientific computing and functional genomics tools and analyses.
• Participate in preparing accessible resources/databases for the community-wide fruition of the data generated within the research programs.

Mandatory requirements :

• Either a PhD or a Masters-level degree in genomics, computational biology and/or bioinformatics applied to any area of biology.
• Knowledge of at least one widely-used programming language (e.g. R or Python), and experience working with the Unix command-line and high-performance cluster computing.
• Proven experience and skills in computational biology and/or bioinformatics, data processing and analysis of a diverse range of data types, including large-scale sequencing data.
• Fluency in English - HT is an international research institute.

Preferential requirements : The following skills and experiences are not essential, but would be advantageous:

• Experience in Functional Genomics would be a strong advantage; for example.
• long-read and direct RNA sequencing.
• other types of RNA sequencing assays and analyses (e.g. single-cell sequencing, isoform-level analyses, Ribo-seq).
• chromatin-level assays (e.g. HiC, ChIP-seq, ATAQ-seq).
• Advanced experience of reproduceable research (eg. git) and/or repoduceable software development (eg. R package development) and/or pipeline development (eg. nextflow, snakemake).
• Experience analysing imaging/microscopy data.
• Knowledge and interest in Machine Learning.

Required personal skills :

• Ability to manage competing priorities in a fast-paced environment and to work independently.
• Strong interpersonal skills demonstrated by the ability to lead and gain the assistance and cooperation of others in a team endeavour. Willingness to train, lead and mentor colleagues.
• Ability to build trust through operating with transparency and creating an open and positive environment.
• Ability to work in a multi-cultural, multi-ethnic environment with sensitivity and respect for diversity.
• Excellent trouble-shooting skills.

Application Instructions :

• a CV
• a motivation letter in English
• the name and contact details of at least 2 potential referees.

Why Human Technopole

HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.

Our working environment is internation